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ea0029p1795 | Thyroid cancer | ICEECE2012

Ret somatic mutations are not an early event in the tumoral transformation of sporadic medullary thyroid cancer

Romei C. , Cosci B. , Ugolini C. , Bottici V. , Molinaro E. , Agate L. , Tacito A. , Basolo F. , Miccoli P. , Pinchera A. , Elisei R.

The reported prevalence of RET somatic mutations in sporadic MTC is about 4050% and the most frequent somatic mutation is Met918Thr in exon 16. MTC harboring a somatic RET mutation have been demonstrated to have a more advanced stage at diagnosis and a worse outcome. Although RET mutations are believed to be driving events in the MTC tumorigenesis only the finding of somatic mutations in microMTC can confirm this hypothesis.Aim of the present work ...

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ea0011p871 | Thyroid | ECE2006

Usefulness of molecular analysis of BRAF mutation and RET/PTC rearrangements in fine needle aspiration (FNA) of thyroid nodules with nondiagnostic cytology

Romei C , Rago T , Scutari M , Bottici V , Di Coscio G , Basolo F , Berti P , Pinchera A , Vitti P , Elisei R

About 1015% of FNA cytologies are nondiagnostic, because of inadequate material or indeterminate (i.e. follicular neoplasms). Aim of this study was to analyse the practical usefulness of the analysis of BRAF mutations and RET/PTC rearrangements, known to be associated to papillary thyroid carcinoma (PTC), in FNA-material.We analysed 100 thyroid nodules with a nondiagnostic cytology: 75 follicular nodules and 25 cases with inadequate material. Fifte...

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Endocrine Abstracts

Ret somatic mutations are not an early event in the tumoral transformation of sporadic medullary thyroid cancer

Usefulness of molecular analysis of BRAF mutation and RET/PTC rearrangements in fine needle aspiration (FNA) of thyroid nodules with nondiagnostic cytology

BiosciAbstracts